Abstract
IN order that a blocking substituent may be utilized for masking the amino function of an amino-acid used in peptide synthesis, it must satisfy a number of requirements. These include the ready availability and stability of the derivatives which incorporate the blocking substituent, and the selective removal of the protecting group under conditions that will not lead to racemization or destruction of the labile peptide molecule.
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References
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Wieland, T., and Schäfer, W., Ann., 576, 104 (1952).
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HALPERN, B., JAMES, L. A New Amino Protecting Group for Amino-acids in Peptide Synthesis. Nature 202, 592–593 (1964). https://doi.org/10.1038/202592a0
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DOI: https://doi.org/10.1038/202592a0
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