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Diffusion Delay in Frog Skin Connective Tissue: a Source of Error in Tracer Investigations

Nature volume 201, pages 932–933 (1964)Cite this article

Abstract

PREVIOUS investigations of tracer kinetics across frog skin have assumed that the connective tissue layer of the corium does not present a significant diffusion barrier1,2. Thus, a simple analysis assuming a one-compartment model was used to estimate the sodium pool size and the fluxes across the epithelial cell borders. However, the present experiments indicate that the connective tissue layer is a significant diffusion barrier.

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References

  1. Hoshiko, T., and Ussing, H. H., Acta Physiol. Scand., 49, 75 (1960).

    Article  Google Scholar 

  2. Curran, P. F., Herrera, F. G., and Flanigan, W. J., J. Gen. Physiol., 45, 1011 (1963).

    Article  Google Scholar 

  3. Huf, E. G., Wills, J., and Arrighi, M. F., J. Gen. Physiol., 38, 867 (1955).

    Article  CAS  Google Scholar 

  4. Crank, J., The Mathematics of Diffusion, 45 (Oxford, London, 1957).

    Google Scholar 

  5. Lindley, B. D., and Hoshiko, T. (in preparation).

  6. Robertson, J. S., Chap. 19 in Handbook of Physiology, Sect. 2, Circulation, 1, 635 (Amer. Physiol. Soc., Washington, 1962).

    Google Scholar 

  7. Cerijido, M., Herrera, F. G., Flanigan, W. J., and Curran, P. F. (private communication).

  8. Worthing, A. G., and Geffner, J., Treatment of Experimental Data (Wiley New York, 1943).

    Google Scholar 

  9. Stevens, W. L., Biometrics, 7, 247 (1951).

    Article  MathSciNet  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Western Reserve University, School of Medicine, Cleveland, Ohio

    T. HOSHIKO & BARRY D. LINDLEY

  2. Department of Physiology, University of Minnesota, Minneapolis

    CHARLES EDWARDS

Authors
  1. T. HOSHIKO
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  2. BARRY D. LINDLEY
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  3. CHARLES EDWARDS
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HOSHIKO, T., LINDLEY, B. & EDWARDS, C. Diffusion Delay in Frog Skin Connective Tissue: a Source of Error in Tracer Investigations. Nature 201, 932–933 (1964). https://doi.org/10.1038/201932a0

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  • DOI: https://doi.org/10.1038/201932a0

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