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Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

Nature volume 339, pages 679–684 (1989)Cite this article

Abstract

Actively transcribing eukaryotic RNA polymerase II is highly phosphorylated on its repetitive carboxyl-terminal domain. We have isolated a protein kinase that phosphorylates serine residues in this repetitive domain. A component of this kinase is cdc2, the product of a cell-cycle control gene previously shown to be a component of M-phase-promoting factor and M-phase-specific histone H1 kinase. This observation suggests a role for the cdc2 protein kinase in transcriptional regulation.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA

    Lars J. Cisek & Jeffry L. Corden

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  1. Lars J. Cisek
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  2. Jeffry L. Corden
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Cisek, L., Corden, J. Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2. Nature 339, 679–684 (1989). https://doi.org/10.1038/339679a0

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