Abstract
It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5′ transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dμ messenger RNA which contains the DJH segments linked to the μ heavy-chain constant region. If the D is joined to the JH segment in the appropriate translational reading frame, this Dμ mRNA is translated to yield a short Dμ protein with a variable DJH N-terminus.
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Reth, M., Alt, F. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature 312, 418–423 (1984). https://doi.org/10.1038/312418a0
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DOI: https://doi.org/10.1038/312418a0
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