Abstract
Hydroxyurea was administered intraperitoneally to pregnant albino rats in a single dose of 2000 mg/kg on day 14 of gestation. Both the perinatal and postnatal mortality rates of the progeny were increased and their weight gain reduced. Exploratory locomotion of 32-day-old rats, calculated by means of an ‘activity index’, was significantly reduced. The treatment had no effect on the brain weight. The fertility of the progeny was not impaired.
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References
B.P.F. Adlard andJ. Dobbing,Maze Learning by Adult Rats after Inhibition of Neuronal Multiplication in utero, Pediat. Res.9, 139–142 (1975).
D.E. Bergsagel,Megaloblastic Erythropoiesis Induced by Hydroxyurea (NSC-32065), Canc. Chem. Rep.40, 15–17 (1964).
J. Brachet,Effects of Hydroxyurea on Development and Regeneration, Nature214, 1132–1133 (1967).
R.L. Brunner, M. McLean, C.V. Vorhees andR. Butcher,A Comparison of Behavioral and Anatomical Measures of Hydroxyurea Induced Abnormalities, Teratology18, 379–384 (1978).
R.E. Butcher, W.J. Scott, K. Kazmaier andE.J. Ritter,Postnatal Effects in Rats of Prenatal Treatment with Hydroxyurea, Teratology7, 161–166 (1973).
S. Chaube andL. Murphy,The Effects of Hydroxyurea and Related Compounds on the Rat Fetus, Cancer Res.26, 1448–1457 (1966).
R. Herken, H.-J. Merker andR. Krowke,Investigation of the Effect of Hydroxyurea on the Cell Cycle and the Development of Necrosis in the Embryonic CNS of Mice, Teratology18, 103–118 (1978).
B. Klionsky andJ.S. Wigglesworth,Production of Experimental Models of Foetal Growth Retardation by Inhibition of DNA or Protein Synthesis, Br. J. exp. Path.51, 361–371 (1970).
T. von Kreybig, Chemische Konstitution und teratogene Wirkung in einigen Verbindungsgruppen, Arch. Pharmakol. Exp. Pathol.257, 296–298 (1967).
T. von Kreybig, R. Preussmann andW. Schmidt,Chemische Konstitution und teratogene Wirkung bei der Ratte, Arzneimittelforsch.18, 645–657 (1968)
R. Krowke andG. Bochert,Inhibition of RNA Synthesis, a Possible Mode of the Embryotoxic Action of Hydroxyurea, Naunyn-Schmiedeberg's Arch. Pharmakol.228, 7–16 (1975).
M.L. Murphy andS. Chaube,Preliminary Survey of Hydroxyurea (NSC-32065) as a Teratogen, Cancer Chem. Rep.40, 1 (1964).
F.S. Philips, S.S. Sternberg, H.S. Schwartz, A.P. Cronin, J.E. Sodergren andP.M. Vidal,Hydroxyurea. 1. Acute Cell Death in Proliferating Tissues in Rats, Cancer Res.27, 61–74 (1967).
W.J. Scott, E.J. Ritter andJ.G. Wilson,DNA Synthesis Inhibition and Cell Death Associated with Hydroxyurea Teratogenesis in Rat Embryos, Develop. Bol.26, 306–315 (1971.
S. Soukup, E. Takacs andJ. Warkany,Chromosome Changes in Embryos Treated with Various Teratogens, J. Embryol. exp. Morph.18, 215–216 (1967).
J.G. Wilson, W.J. Scott, E.J. Ritter andR. Fradkin,Comparative Distribution and Embryotoxicity of Hydroxyurea in Pregnant Rats and Rhesus Monkeys, Teratology11, 169–178 (1975).
J.W. Yarbro,Further Studies do the Mechanism of Action of Hydroxyure, Cancer Res.28, 1082–1087 (1968).
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Fritz, H., Hess, R. Effects of hydroxyurea on postnatal growth and behaviour of rats. Agents and Actions 10, 389–393 (1980). https://doi.org/10.1007/BF01971445
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DOI: https://doi.org/10.1007/BF01971445