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Influence of zinc, D-penicillamine and oxygen on poisoning withAmanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom

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Abstract

Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroomAmanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight.d-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.

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Authors and Affiliations

  1. Department of Surgery and Research, Zentrum für Lehre und Forschung, Hebelstrasse 20, CH-4031, Basel, Switzerland

    G. L. Floersheim, N. Chiodetti & C. G. Honegger

  2. Department of Pathology, Kantonsspital, CH-4031, Basel, Switzerland

    L. Bianchi & A. Probst

Authors
  1. G. L. Floersheim
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  2. L. Bianchi
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  3. A. Probst
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  4. N. Chiodetti
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  5. C. G. Honegger
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Floersheim, G.L., Bianchi, L., Probst, A. et al. Influence of zinc, D-penicillamine and oxygen on poisoning withAmanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom. Agents and Actions 14, 124–130 (1984). https://doi.org/10.1007/BF01966845

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  • DOI: https://doi.org/10.1007/BF01966845

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