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Prostacyclin increases filterability of normal and rigidified human red blood cellsin vitro

  • Platelets and Thrombosis
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Abstract

Red blood cell (RBC) deformability is a critical determinant of capillary flow. In a previous study we found decreased deformability (filterability) of red cells of patients with clinical symptoms of peripheral ischaemia associated with systemic sclerosis and prostacyclin (PGI2) infusion had beneficial effect on both the clinical symptoms and red cell filterability. The present study was therefore designed to investigate the effect of PGI2 on RBC deformabilityin vitro, by measuring the filterability of RBCs suspended in saline. The results demonstrate that PGI2 increases filterabillty of normal RBCs and significantly improves the impaired deformability of cells due to storage or calcium influx.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, St Bartholomew's Hospital Medical School, EC1A 7BE, London

    Iren B. Kovacs & J. O'Grady

  2. Department of Clinical Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, UK

    Iren B. Kovacs & J. O'Grady

Authors
  1. Iren B. Kovacs
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  2. J. O'Grady
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Kovacs, I.B., O'Grady, J. Prostacyclin increases filterability of normal and rigidified human red blood cellsin vitro . Agents and Actions 14, 306–310 (1984). https://doi.org/10.1007/BF01966658

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  • DOI: https://doi.org/10.1007/BF01966658

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