Abstract
After an i.v. application of 100 mg tramadol in 13 healthy volunteers (1) no change in plasma histamine concentration could be detected, (2) systemic anaphylactoid reactions did not occur, (3) cutaneous reactions were not rated as anaphylactoid since itching and erythema were seen only once after tramadol whereas erythema was also observed twice after saline, (4) blood pressure and heart rate were only very slightly and transiently elevated without any abnormalities in ECG-readings and (5) only side effects typical for opioid therapy were observed.
Similar content being viewed by others
References
D. M. Philbin, J. Moss, C. E. Rosow, C. W. Akins and J. L. Rosenberger,Histamine release with intravenous narcotics: Protective effects of H 1-and H 2-receptor antagonists. Klin. Wschr.60, 1056–1059 (1982).
S. Berg-Seiter, B. Koßmann, W. Dick and W. Lorenz,Untersuchungen zum Verhalten der Plasmahistaminspiegel nach periduraler Morphinapplikation. Anästhesist34, 388–391 (1985).
J. Watkins and J. A. Thornton,Immunological and non-immunological mechanisms involved in adverse reactions to drug. Klin. Wschr.60, 958–964 (1982).
A. Doenicke, W. Lorenz, H. Suttmann, T. H. Duka, C. H. Bretz and A. Schmal,Alfentanil/Fentanyl — Histaminfreisetzung und Katecholamine. In:Histamin und Histamin-Rezeptor-Antagonisten, pp. 25–38. Springer Verlag, Berlin Heidelberg New York Tokyo 1985.
W. Lorenz, A. Doenicke, B. Schöning, C. H. Ohmann, B. Grote and E. Neugebauer,Definition and classification of the histamine release response to drugs in anesthesia and surgery: studies in the conscious human subject. Klin. Wschr.60, 896–913 (1982).
W. Lorenz, H. J. Reimann, H. Barth, J. Kusche, R. Meyer, A. Doenicke and M. Hutzel,A sensitive and specific method for the determination of histamine in human whole blood and plasma. Hoppe-Seyler's Z. Physiol. Chem.353, 911–920 (1972).
W. Lorenz and A. Doenicke,Histamine release in clinical conditions. Mount Sinai J. Med.45, 357–386 (1978).
W. Lorenz and A. Doenicke,H 1-and H 2-blockade: a prophylactic principle in anesthesia and surgery against histamine release responses of any degree of severity. New Engl. Reg. Allergy Proc., part I:6, 37–97 (1985); part II:6, 174–194 (1985).
P. V. Scott and H. B. J. Fischer,Intraspinal opiates and itching: a new reflex. Brit. Med. J.284, 1015–1016 (1982).
H. H. Hennies, E. Friderichs, K. Wilsmann and L. Flohé,Effect of the opioid analgesic tramadol on inactivation of norepinephrin and serotonin. Biochem. Pharmacol.31, 1654–1655 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barth, H., Giertz, H., Schmal, A. et al. Anaphylactoid reactions and histamine release do not occur after application of the opioid tramadol. Agents and Actions 20, 310–313 (1987). https://doi.org/10.1007/BF02074699
Issue Date:
DOI: https://doi.org/10.1007/BF02074699