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Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats

  • Immunosuppression and Inflammation
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Abstract

The gastrointestinal toxicity of a single oral administration of five nonsteroidal anti-inflammatory agents (NSAIDs) to rats was compared, by a method using51Cr-labeled red blood cells (RBC), and by macroscopic and microscopic examination. From the profile of gastrointestinal bleeding, the NSAIDs could be divided into a group consisting of aspirin (ASA), oxaprozin (OXP) and 2-[4-(3-methyl-2-butenyl)phenyl]propionic acid (TA), which caused only a transient increase in fecal blood loss based on a gastric lesion, and another group including indomethacin (IM) and ibuprofen (IP), which produced a biphasic increase in the blood loss. The initial phase was caused not only by a gastric lesion but also an intestinal lesion, and the secondary phase originated only in the intestinal lesion. The order of potency causing blood loss was IM≫IP>ASA≫TA>OXP. The safety ratio of OXP and TA was shown to be more favorable than that of the other three drugs.

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Authors and Affiliations

  1. Research Center, Taisho Pharmaceutical Co., Ltd., 330, Ohmiya, Saitama, Japan

    T. Suwa, H. Urano, Y. Kohno, A. Suzuki & T. Amano

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  1. T. Suwa
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  2. H. Urano
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  3. Y. Kohno
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  4. A. Suzuki
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  5. T. Amano
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Suwa, T., Urano, H., Kohno, Y. et al. Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats. Agents and Actions 21, 167–172 (1987). https://doi.org/10.1007/BF01974937

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  • DOI: https://doi.org/10.1007/BF01974937

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