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Failure of PAF-acether to inducein vivo neutrophil migration

  • Platelets and Thrombosis
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Abstract

The ability of PAF-acether (platelet activating factor, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to induce neutrophil migration was tested in the peritoneal cavities of rats and guinea-pigs and in rat skin air pouches. PAF-acether, at doses of 2 and 5 μg per animal, did not promote significant neutrophil migration. The ability of PAF-acether antagonists to inhibit carrageenin induced neutrophil migration in rat abdominal cavities was also investigated. Carrageenin is a substance described to cause the release of endogenous PAF-acether. Neutrophil migration was not affected by PAF-antagonists. These observations challenge the possible role of PAF-acether as a neutrophil chemotactic factorin vivo.

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Authors and Affiliations

  1. Department of Pharmacology of the Faculty of Medicine, University of São Paulo, 14049, Ribeirão Preto, SP., Brazil

    F. Q. Cunha, N. E. Heluy-Neto, A. Klein, G. E. P. Souza &  S. H. Ferreira

  2. the Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14049, Ribeirão Preto, SP., Brazil

    F. Q. Cunha, N. E. Heluy-Neto, A. Klein, G. E. P. Souza &  S. H. Ferreira

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  1. F. Q. Cunha
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  2. N. E. Heluy-Neto
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  3. A. Klein
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  4. G. E. P. Souza
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  5. S. H. Ferreira
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Cunha, F.Q., Heluy-Neto, N.E., Klein, A. et al. Failure of PAF-acether to inducein vivo neutrophil migration. Agents and Actions 25, 191–194 (1988). https://doi.org/10.1007/BF01969111

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  • DOI: https://doi.org/10.1007/BF01969111

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