Skip to main content
SpringerLink
Log in

A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints

  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT2-antogonist, ketanserin, but not by the 5-HT3-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. Guilbaud, A. Iggo and R. Tegner,Sensory receptors in ankle joint capsules of normal and arthritic rats. Exp. Brain Res.58, 29–40 (1985).

    PubMed  Google Scholar 

  2. G. Guilbaud and A. Iggo,The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyarthritis. Exp. Brain. Res.61, 164–168 (1985).

    PubMed  Google Scholar 

  3. P. Grigg, H.-G. Schaible and R. F. Schmidt,Mechanical sensitivity of group III and IV afferents from posterior articular nerve in normal and inflamed cat knee. J. Neurophysiol.55, 635–643 (1986).

    PubMed  Google Scholar 

  4. D. A. A. Owen,Vascular changes during acute inflammatory responses in rat hind paws. InPerspectives in inflammation (Eds. D. A. Willoughby, J. P. Giroud and G. P. Velo) pp 491–495 MTP Press, London 1977.

    Google Scholar 

  5. B. P. Richardson, G. Engel, P. Donatsch and P. A. Stadler,Identification of 5-hydroxytryptamine M-receptor subtypes and their specific blockade by a new class of drugs. Nature316, 126–131 (1985).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Preclinical Veterinary Sciences, R.(D), S.V.S. University of Edinburgh, Summerhall, EH9 1QH, Edinburgh, UK

    B. D. Grubb & A. Iggo

  2. Department of Pharmacology, University of Edinburgh Medical School, 1, George Square, EH8 9JZ, Edinburgh, UK

    D. S. McQueen & G. J. Birrell

  3. Department of Physiology, University of Edinburgh Medical School, Teviot Place, EH8 9AG, Edinburgh, UK

    M. B. Dutia

Authors
  1. B. D. Grubb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. S. McQueen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Iggo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. J. Birrell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. B. Dutia
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grubb, B.D., McQueen, D.S., Iggo, A. et al. A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints. Agents and Actions 25, 216–218 (1988). https://doi.org/10.1007/BF01965015

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01965015

Keywords

Search

Navigation