Skip to main content
SpringerLink
Log in

Histamine-releasing activity of mouse spleen cell culture supernatants

  • Histamine Release from Murine Serosal Mast Cells and Human Basophils
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Histamine releasing factor (HRF) generatedin vitro by spleen cells of immunized mice activates homologous peritoneal mast cells (both normal and sensitized) for small but consistent, dose-dependent histamine and 5-hydroxytryptamine release. Both the time-course of this release and its susceptibility to the enhancing effect of D2O were similar to those observed in IgE-induced release; however, simultaneous challenge of sensitized mast cells with HRF and specific antigen or anti-IgE showed an additive effect, suggesting that mediator release by HRF and by the IgE system are independent of one another.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. Thueson, L. S. Speck, M. A. Lett-Brown and J. A. Grant,Histamine-releasing activity. I. Production by mitogen- or antigen-stimulated human mononuclear cells. J. Immunol.123, 626–632 (1979).

    PubMed  Google Scholar 

  2. D. Thueson, L. S. Speck, M. A. Lett-Brown and J. A. Grant,Histamine-releasing activity. II. Interaction with basophils and physicochemical characterization. J. Immunol.123, 633–639 (1979).

    PubMed  Google Scholar 

  3. J. C. Ezeamuzie and E. S. K. Assem,A study of histamine release from human basophils and lung mast cells by products of lymphocyte stimulation. Agents and Actions13, 222–230 (1983).

    PubMed  Google Scholar 

  4. R. Alam, J. Rozniecki and K. Selmaj,A mononuclear cell derived histamine releasing factor (HRF) in asthmatic patients. Histamine release from basophils in vitro. Ann. Allergy53, 66–69 (1984).

    PubMed  Google Scholar 

  5. A. P. Kaplan, M. Haak-Frendscho, A. Fauci, C. Dinarello and E. Halbert,A histamine releasing factor from activated human mononuclear cells. J. Immunol.135, 2027–2032 (1985).

    PubMed  Google Scholar 

  6. R. Alam, J. Wyczóŀkowska and Z. Suŀowska,Studies on histamine releasing factor (HRF) of human, murine and guinea-pig origin. Agents and Actions18, 163–166 (1986).

    PubMed  Google Scholar 

  7. J. Wyczóŀkowska and Cz. Maśliński,Action of anti-mouse IgE on mouse and rat mast cells. Acta Allergol.31, 175–183 (1976).

    PubMed  Google Scholar 

  8. J. A. Otsuki, R. Grassick, D. Seymour and L. S. Kind,The use of 3 H-serotonin release from mast cells of the mouse as an assay for mediator liberation. Immunol. Commun.5, 27–39 (1976).

    PubMed  Google Scholar 

  9. R. Alam and J. Wyczóŀkowska,Action of the human lymphokine—histamine releasing factor (HRF) on mouse peritoneal mast cells. Immunol. Lett.11, 111–115 (1985).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biogenic Amines, Polish Academy of Sciences, Tylna 3, 90-950, Łódź, Poland

    J. Wyczóŀkowska, Z. Suŀowska & E. Brzenińska-Bŀaszczyk

Authors
  1. J. Wyczóŀkowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Suŀowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Brzenińska-Bŀaszczyk
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wyczóŀkowska, J., Suŀowska, Z. & Brzenińska-Bŀaszczyk, E. Histamine-releasing activity of mouse spleen cell culture supernatants. Agents and Actions 27, 46–48 (1989). https://doi.org/10.1007/BF02222194

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02222194

Keywords

Search

Navigation