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Occurrence of a complement activator in human urine

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Abstract

It is known that in rats, heterologous nephrotoxic serum (rabbit antirat kidney) produces an acute hemorrhagic pneumonitis. Administration of anticomplementary substances such as heat aggregated human γ-globulin and zymosan, protects the animal from the pneumotoxic activity of nephrotoxic serum. Previous work has disclosed the presence of an anticomplementary substance isolated from normal urine by gel filtration that proved also effective in this regard. The present communication deals with some of the work developed in order to study the mechanism of the anticomplementary activity exhibited by the urinary substance. The preliminary findings are suggestive that the anticomplementary effect is the result of an activation of the complement system provoked by the urinary substance.

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References

  1. I. F. de Carvalho, H. L. Oliveira, J. A. Laus-Filho andW. Sarti,Prevention of Acute Immunological Lung Lesion in Rats by Decomplementing Treatment, Immunology16, 633–641 (1969).

    PubMed  Google Scholar 

  2. W. Dias da Silva, N. R. Vieira Maria andC. R. Diniz,The Role of the Complement System in the Pathogenesis of Acute Pulmonary Oedema Produced by Nephrotoxic Serum in Rats, Clin. exp. Immun.6, 395–406 (1970).

    PubMed  Google Scholar 

  3. H. L. Oliveira, J. A. Laus-Filho andW. Sarti,Prevention of Acute Immunological Lung Change by Previously Induced Acute Uremia in Rats, Int. Arch. Allergy29, 384–392 (1966).

    PubMed  Google Scholar 

  4. A. Pasternack Pulmonary Changes in Acute Experimental Uremia in Rats, Acta med. scand.176, 675–679 (1964).

    PubMed  Google Scholar 

  5. H. L. Oliveira, J. A. Laus-Filho, W. Sarti andI. F. de Carvalho,Prevention of Acute Immunologic Lung Change in Rats by an Isolated Urine Fraction, Int. Arch. Allergy31, 551–558 (1967).

    PubMed  Google Scholar 

  6. I. F. de Carvalho, H. L. Oliveira, J. A. Laus-Filho andW. Sarti,Studies on the Suppression of Acute Immune Lung Change in Rats by Decomplementing Procedures, Acta physiol. lat.-am.19, 161–162 (1969).

    Google Scholar 

  7. I. F. de Carvalho andW. Sarti,Experimenta. Immunological Lung Lesion in Rats and Guinea-Pigsl Studies on the Mechanism of Pulmonary Damage, Immunopathology—VIth International Symposium (Ed. P. A. Miescher; Schwabe & Co. Publishers, Basel and Stuttgart 1970), p. 366–375.

    Google Scholar 

  8. M. M. Mayer, in:Kabat and Mayer's Experimental Immunochemistry, 2nd ed. (Eds E. A. Kabat and M. M. Mayer; Charles C. Thomas, Springfield, Ill. 1961).

    Google Scholar 

  9. J. J. Scheidegger,Une micro-méthode l'immunoélectrophorese, Int. Arch. Allergy and appl. Immun.7, 103 (1955).

    Google Scholar 

  10. O. Gotze andH. J. Muller-Eberhard,The C3-Activator System: an Alternate Pathway of Complement Activation, J. exp. Med.134, 90si-08s (1971).

    Google Scholar 

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  1. Department of Internal Medicine, Faculty of Medicine, USP, Ribeirão Prêto, SP, Brazil

    I. F. de Carvalho

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  1. I. F. de Carvalho
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de Carvalho, I.F. Occurrence of a complement activator in human urine. Agents and Actions 3, 344–347 (1973). https://doi.org/10.1007/BF01986492

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  • DOI: https://doi.org/10.1007/BF01986492

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