Abstract
The effects of the novel antiasthmatic/antiallergic compound flezelastine on LPS-induced actions were investigatedin vitro andin vivo. In monocytes, IL-1β generation stimulated by LPS was inhibited dose dependently.In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1β, was also inhibited by flezelastine. These findings suggest that flezelastine inhibits IL-1 synthesis and/or releasein vitro andin vivo.
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Werner, U., Schmidt, J. & Szelenyi, I. Effects of flezelastine and its enantiomers on LPS-induced IL-1β generationin vitro and LPS-induced pyrexiain vivo . Agents and Actions 41, 99–100 (1994). https://doi.org/10.1007/BF01986405
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DOI: https://doi.org/10.1007/BF01986405