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Neutrophil depletion does not prevent indomethacin-induced ulceration of the rat gastric antrum

  • Proceedings of the Joint World Congress of the International Association of Inflammation Societies and the European Inflammation Society, Austria Center, Vienna, October 10–15, 1993
  • Neutrophils, Nitric Oxide and Gut Inflammation
  • Published:
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Abstract

Indomethacin-induced ulceration of the rat gastric antrum is paralleled by an increase in blood neutrophil numbers and of neutrophil infiltration into the antrum. Thus, in this study, neutrophil depletion has been employed to study the potential role of neutrophils in the pathogenesis of indomethacin-induced ulceration of the rat gastric antrum. Pretreatment with an anti-neutrophil serum (ANS) induced a near complete neutropaenia and inhibition of neutrophil infiltration into the gastric antrum (as assessed by antral LTB4 release). In contrast, ANS pretreatment did not alter the area of indomethacin-induced mucosal damage detected microscopically.

Our results suggest that, in contrast to published reports examining fundic ulceration, neutrophil infiltration does not contribute to the ulcerogenic effects of indomethacin in the rat gastric antrum.

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References

  1. J. L. Wallace, C. M. Keenan and D. N. Granger,Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil dependent process. Am. J. Physiol.259, G462-G467 (1990).

    PubMed  Google Scholar 

  2. M. Lee, K. Aldred, E. Lee and M. Feldman,Aspirin-induced acute gastric mucosal injury is a neutrophil dependent process. Am. J. Physiol.263, G920-G926 (1992).

    PubMed  Google Scholar 

  3. J. L. Wallace, K. E. Arfors and G. W. McKnight,A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin induced gastric damage in the rabbit. Gastroenterology100, 878–883 (1991).

    PubMed  Google Scholar 

  4. M. A. Trevethick, N. M. Clayton, P. Strong and I. Harman,Do infiltrating neutrophils contribute to the pathogenesis of indomethacin-induced ulceration of the rat gastric antrum? Gut34, 156–160 (1993).

    PubMed  Google Scholar 

  5. H. Sandler, H. Högstorp, C. Lundberg and B. Gerdin,Antiserum-induced neutropaenia in the rat: Characterisation of the rabbit anti-rat neutrophil serum. Br. J. Exp. Path68, 71–80 (1987).

    Google Scholar 

  6. J. L. Wallace and D. N. Granger,Pathogenesis of NSAID-induced gastropathy: Are neutrophils the culprits? TIPS13, 129–131 (1992).

    PubMed  Google Scholar 

  7. S. H. Roth and R. E. Bennett,Nonsteroidal anti-inflammatory drug gastropathy: Recognition and response. Arch. Int. med.147, 2093–2100 (1987).

    Article  Google Scholar 

  8. K. P. Stock and G. L. Bach,Ulcer healing with ranitidine and antacids despite continued treatment with non steroidal anti-inflammatory drugs. Z. Rheumatol.47, 177–181 (1988).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastrointestinal, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK

    M. A. Trevethick, N. M. Clayton & A. K. Bahl

  2. Department of Cardiovascular and Respiratory Pharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK

    S. Sanjar & P. Strong

Authors
  1. M. A. Trevethick
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  2. N. M. Clayton
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  3. A. K. Bahl
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  4. S. Sanjar
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  5. P. Strong
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Trevethick, M.A., Clayton, N.M., Bahl, A.K. et al. Neutrophil depletion does not prevent indomethacin-induced ulceration of the rat gastric antrum. Agents and Actions 41 (Suppl 2), C226–C227 (1994). https://doi.org/10.1007/BF01987647

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  • DOI: https://doi.org/10.1007/BF01987647

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