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Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes: Possible role of prostaglandin E2

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Abstract

We investigated the importance of prostaglandin E2 (PGE2) release in interleukin-1 (IL-1)-induced inhibition of aggrecan synthesis by chondrocytes. Keratan sulfate (KS) production was measured in parallel with PGE2 release in chondrocytes. IL-1 inhibited KS production and stimulated PGE2 release. In the presence of PGE2, there was a dosedependent decrease in baseline KS production. Indomethacin and dexamethasone partially blocked the IL-1-induced PGE2 release while KS production recovered. Our results suggest that IL-1 inhibits KS production, in part, by stimulating the release of PGE2.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kinki University School of Medicine, Ohnohigashi 377-2, Osaka-sayama, 589, Osaka, Japan

    K. Fukuda, K. Ohtani, H. Dan & S. Tanaka

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  1. K. Fukuda
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  2. K. Ohtani
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  3. H. Dan
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  4. S. Tanaka
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Fukuda, K., Ohtani, K., Dan, H. et al. Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes: Possible role of prostaglandin E2. Inflamm Res 44, 178–181 (1995). https://doi.org/10.1007/BF01782816

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  • DOI: https://doi.org/10.1007/BF01782816

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