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The effects of mesoporphyrin on experimental arthritis in mice

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Abstract

The effects of mesoporphyrin, a novel porphyrin derivative, on type II collagen-induced arthritis in mice were studied. Mesoporphyrin (10–30 mg/kg) and prednisolone (5 mg/kg; reference drug) reduced the incidence and severity of type II collagen-induced arthritis in mice, as assayed by clinical observation and histopathological studies. Although both agents inhibited type II collagen-induced delayed type hypersensitivity in arthritic mice, only prednisolone inhibited humoral immunity to type II collagen. The effects of mesoporphyrin on T cell dependent allergic inflammation were examined, in order to study the mechanism by which it inhibits arthritis. Staphylococcal enterotoxin B (SEB; superantigen)-potentiated collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity reaction were clearly inhibited by mesoporphyrin. Moreover, the superantigen-induced CD-25 expression on T cells was inhibited by mesoporphyrin. These results indicate that mesoporphyrin inhibits type II collagen-induced arthritis by inhibiting the activation of T cells.

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Authors and Affiliations

  1. Department of Pharmacology, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, 502, Gifu, Japan

    H. Nagai, Y. Takaoka & H. Mori

  2. Immunological and Cardiovascular Research Laboratory, Taiho Pharmaceutical Co. Ltd., 216-1 Nakayashita Yaoroshi Hannou, 357, Saitama, Japan

    N. Matsuura

Authors
  1. H. Nagai
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  2. Y. Takaoka
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  3. H. Mori
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  4. N. Matsuura
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accepted by M. Katori

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Nagai, H., Takaoka, Y., Mori, H. et al. The effects of mesoporphyrin on experimental arthritis in mice. Inflamm Res 45, 293–298 (1996). https://doi.org/10.1007/BF02280994

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  • DOI: https://doi.org/10.1007/BF02280994

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