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Interaction between enoxacin, a new antimicrobial, and nimesulide, a new non-steroidal anti-inflammatory agent in mice

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Abstract

Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. The oral administration of nimesulide alone induced clonic convulsions at more than 300 mg/kg. The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg. The combination of nimesulide at 200 mg/kg and enoxacin at 400 mg/kg induced no convulsion. In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion. These results suggest that the combination of nimesulide and enoxacin may possibly induce few or less convulsions in the clinical setting.

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References

  1. Pharmaceuticals and Chemicals safety Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare of Japan. Information on Adverse Reactions to Drugs No. 81: Convulsions induced by interaction between enoxacin and fenbufen. Jpn Med J 1986; 3263:101–2.

    Google Scholar 

  2. Pharmaceuticals and Chemicals Safety Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare of Japan. Information on Adverse Reactions to Drugs No. 98: Interaction between new quinolone antimicrobials and nonsteroidal anti-inflammatory drugs (Convulsions). Jpn Med J 1989; 3415:180–1.

    Google Scholar 

  3. Hori S, Shimada J, Miyata T, Kurioka S, Matsuda M. Studies on the mechanism of induction of convulsions by quinolone antimicrobials. Neurochem 1987;26:178–80.

    Google Scholar 

  4. Taniguchi Y, Ikesue A, Yokoyama K, Noda K, Debuchi H, Nakamura T, et al. Selective inhibition by nimesulide, a novel non-steroidal anti-inflammatory drugs, with prostaglandin endoperoxide synthase-2 activity in vitro. Pharm Sci 1995;1:173–5.

    Google Scholar 

  5. Nozaki M, Takeda N, Tanaka K, Niwa M, Hozumi K, Kaida T, et al. Convulsions induced by concomitant use of new quinolone antibacterial and NSAID. Jpn J Inflamm 1991;11:343–8.

    Google Scholar 

  6. Murayama S, Suzuki T, Hara Y, Tamagawa M, Kakizaki K. Unusual central action of new quinolone group of antimicrobials. Jpn J Pharmacol 1987;43 Suppl:60.

    Google Scholar 

  7. Murayama S. Interaction of new quinolones. Prog Med 1987;7 Suppl 1:2272–5.

    Google Scholar 

  8. Kober A, Sjoholm I. The binding sites on human serum albumin for some non-steroidal antiinflammatory drugs. Mol Pharmacol 1980;18:421–6.

    PubMed  Google Scholar 

  9. Skidmore IF, Whitehouse MW. Effect on non-steroidal anti-inflammatory drugs on aldehyde binding to plasma alubumin: a novel in vitro assay for potential antiinflammatory activity. J Pharm Pharmacol 1965;17:671–3.

    PubMed  Google Scholar 

  10. Murayama S, Hara Y, Ally A, Suzuki T, Tamagawa M. Central stimulating effect of the combination of the new quinolone group of antimicrobials and nonsteroidal anti-inflammatory drugs in mice. Folia Pharmacol Jpn 1992;99:13–8.

    Google Scholar 

  11. Bree F, Nguyen P, Urien S, Albengres E, Macciocchi A, Tillement JP. Nimesulide binding to components within blood. Drugs 1993;46 Suppl 1:83–90.

    PubMed  Google Scholar 

  12. Akahane K, Sekiguchi M, Une T, Osada Y. Structure-epileptogenicity relationship of quinolones with special reference to their interaction with γ-aminobutyric acid receptor cites. Antimicrob. Agents Chemother 1989;33:1704–8.

    PubMed  Google Scholar 

  13. Tsuji A, Sato H, Okezaki E, Nagata O, Kato H. Effect of the anti-inflammatory agent fenbufen on the quinolone-induced inhibition of γ-aminobutyric acid binding to rat brain in vitro. Biochem Pharmacol 1988;37:4408–11.

    Article  PubMed  Google Scholar 

  14. Kono K, Nozaki M, Niwa M, Tsurumi K. Interaction between Zaltoprofen, a novel antiinflammatory drug, and new quinolone anti-microbial drugs: Comparative study of various anti-inflammatory drugs on mice. Pharmacometrics 1994;48:289–96.

    Google Scholar 

  15. hara Y, Ally A, Suzuki T, Murayama S. Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice. Folia Pharmacol Jpn 1992;100:301–5.

    Google Scholar 

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accepted by R.O. Day

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Taniguchi, Y., Deguchi, Y. & Noda, K. Interaction between enoxacin, a new antimicrobial, and nimesulide, a new non-steroidal anti-inflammatory agent in mice. Inflamm Res 45, 376–379 (1996). https://doi.org/10.1007/BF02252931

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  • DOI: https://doi.org/10.1007/BF02252931

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