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The mechanism whereby growth hormone-release inhibiting hormone (somatostatin) inhibits food stimulated gastric acid secretion in the cat

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Abstract

Growth hormone-release inhibiting hormone (somatostatin) inhibits the gastric acid response to food in concious cats. We have confirmed that this tetradecapeptide blocks the food stimulated gastrin release. However, the inhibition of gastrin release is delayed relative to that of acid secretion, showing that the inhibition of food stimulated acid secretion is by a primary effect on the acid secretory mechanism. No evidence was found of potentiation of either the gastric acid output or serum concentration of gastric in response to food.

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Authors and Affiliations

  1. Department of Physiology, University of Newcastle upon Tyne, England

    M. Albinus, E. L. Blair, E. R. Grund, J. D. Reed & D. J. Sanders

  2. Endocrine Unit, Department of Medicine, University of Newcastle upon Tyne, England

    A. Gomez-Pan

  3. Veterans Administration Hospital and Tulane University School of Medicine, New Orleans, Louisiana, USA

    A. V. Schally

  4. The Professorial Medical Unit, St. Bartholomew's Hospital, London, England

    G. M. Besser

Authors
  1. M. Albinus
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  2. E. L. Blair
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  3. E. R. Grund
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  4. J. D. Reed
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  5. D. J. Sanders
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  6. A. Gomez-Pan
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  7. A. V. Schally
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  8. G. M. Besser
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Albinus, M., Blair, E.L., Grund, E.R. et al. The mechanism whereby growth hormone-release inhibiting hormone (somatostatin) inhibits food stimulated gastric acid secretion in the cat. Agents and Actions 5, 306–310 (1975). https://doi.org/10.1007/BF02205235

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  • DOI: https://doi.org/10.1007/BF02205235

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