Abstract
An anti-inflammatory factor (AIF) was highly purified from normal bovine serum. The purified AIF was a polysaccharide which was formed from a low molecular substance Pro-AIF by macromolecularization. AIF showed potent inhibitory activities against carrageenin induced edema in rats and PMN-leucocyte chemotaxis. It showed no inhibition in cutaneous reaction with serotonin, bradykinin or a mediator releaser compound 48/80. No inhibition was also observed in thermally induced pain, reversed passive Arthus reaction and adjuvant polyarthritis in rats. With these results, the role of AIF in inflammation was discussed.
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Misaka, E., Matsuda, K., Kobayashi, K. et al. Purification and characterization of an anti-inflammatory factor (AIF) from bovine serum. Agents and Actions 8, 442–451 (1978). https://doi.org/10.1007/BF01968674
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DOI: https://doi.org/10.1007/BF01968674