Abstract
Mice exhibiting a spontaneous SLE-like lethal autoimmunity (female NZB/W hybrids) were given monthy doses of cyclophosphamide (CPA) 240 mg/kg p.o. starting at four months of age. Antibodies to DNA and sheep red blood cells (SRBC) were measured as well as general well being of the mice. The CPA-treated group demonstrated a marked increased in survival compared to the untreated controls with reduction of anti-DNA antibody levels but only a slight inhibition of the anamnestic response to SRBC immunization.
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Supported in part by USPHS Grant No. GM 15759.
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Levy, L., Chia, D. & Barnett, E.V. Effect of pulse dose cyclophosphamide on the anamnestic immune response in NZB/W mice. Agents and Actions 8, 644–651 (1978). https://doi.org/10.1007/BF01998895
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DOI: https://doi.org/10.1007/BF01998895