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Does the gastric mucosa contain inhibitory histamine H1-receptors?

  • European Branch of Histamine Club
  • Seventh Annual Meeting, May 2–4 1978, Łódź (Poland) Histamine and Gastric Intestinal Secretion
  • Published:
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Conclusion

From the results it is concluded that in contrast to data reported in the literature, in cats histamine, dimaprit and tolazoline produce an identical acid response and differ only in their affinity to the histamine H2-receptor. The effects of mepyramine and phenoxybenzamine do not indicate the presence of H1-receptors, which is confirmed by missing inhibitory effects of PEA. The effects of the former two, however, suggest that reversal of the histamine dose-response curve is caused by histamine-released catecholamines which are prevented from being released by mepyramine and blocked in their peripheral action by phenoxybenzamine.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Tübingen, D-7400, Tübingen, Germany

    M. Albinus

  2. Department of Pathophysiology, Krakowskie, Przedmiescie 26/28, 00-227, Warsaw, Poland

    S. Malinski

Authors
  1. M. Albinus
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  2. S. Malinski
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Albinus, M., Malinski, S. Does the gastric mucosa contain inhibitory histamine H1-receptors?. Agents and Actions 9, 76–77 (1979). https://doi.org/10.1007/BF02024124

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  • DOI: https://doi.org/10.1007/BF02024124

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