Skip to main content
Log in

Differential susceptibility of peripheral nerves of the hen to triorthocresyl phosphate and to trauma

  • Models in Toxicology
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The nerve fibres of largest diameter and of greatest length are considered to be the most vulnerable to triorthocresyl phosphate (TOCP). In this study, the differential vulnerability of the particular sciatic nerve branches was determined in the course of TOCP neuropathy and of Wallerian degeneration. The branch innervating the lateral gastrocnemius muscle, made up predominantly of large-diameter fibres, proved most susceptible to TOCP. By contrast, after proximal sciatic-nerve transection, degeneration commenced in the lateral nerve of the third digit, containing long nerve fibres of small diameter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J.M. Barnes andF.A. Denz,Experimental Demyelination with Organo-Phosphorus Compounds, J. Path. Bact.LXV, 597 (1953).

    Google Scholar 

  2. W.A. Beresford andP. Glees,Denervation in the Long Tracts of the Cords of the Chicken and Cat after Triorthocresylphosphate Poisoning, Acta Neuropath.3, 108 (1963).

    Google Scholar 

  3. A. Bischoff,The Ultrastructure of Tri-Ortho-Cresyl-Phosphate-Poisoning I. Studies on Myelin and Axonal Alterations in the Sciatic Nerve, Acta Neuropath.9, 158 (1967).

    Google Scholar 

  4. A. Bischoff,Ultrastructure of Tri-Ortho-Cresyl-Phosphate Poisoning in the Chicken II. Studies on Spinal Cord Alterations, Acta Neuropath.15, 142 (1970).

    PubMed  Google Scholar 

  5. A. Bischoff,Tri-Ortho-Cresyl-Phosphate Neurotoxicity, in:Neurotoxicology (Eds. L. Roizin, H. Shiraki and N. Grćević; Raven Press, New York, 1977), p. 431.

    Google Scholar 

  6. I.A. Boyd andM.R. Davey,Composition of Peripheral Nerves (E. & S. Livingstone Ltd., Edinburgh and London, 1968), pp. 1–57.

    Google Scholar 

  7. British Working Documents, April 1967, No. 2,Tests for Neurotoxicity of Organo-Phosphorus Compounds (Ministry of Agriculture, Fisheries and Food, London, 1967), pp. 1–6.

  8. J.B. Cavanagh,The Toxic Effects of Tri-Ortho-Cresyl Phosphate on the Nervous System, J. Neurol. Neurosurg. Psychiat.17, 163 (1954).

    Google Scholar 

  9. J.B. Cavanagh andV. MacDermot,Sensory Terminal Degeneration in Ortho-Cresyl Phosphate Poisoning, Lancet2, 583 (1961).

    PubMed  Google Scholar 

  10. J.B. Cavanagh,Organo-Phosphorus Neurotoxicity: A Model ‘Dying Back’ Process Comparable to Certain Human Neurological Disorders, Guy's Hospital Reports (London)112 (3), 303 (1963).

    Google Scholar 

  11. J.R. Donat andH.M. Wiśniewski,The Spatio-Temporal Pattern of Wallerian Degeneration in Mammalian Peripheral Nerves, Brain Research53, 41 (1973).

    PubMed  Google Scholar 

  12. J. Prineas,The Pathogenesis of Dying-Back Polyneuropathies, Part I. An Ultrastructural Study of Experimental Tri-Ortho-Cresyl Phosphate Intoxication in the Cat. J. Neuropath. Exp. Neurol.28, 571 (1969).

    PubMed  Google Scholar 

  13. J. Prineas,The Pathogenesis of Dying-Back Polyneuropathies, Part II. An Ultrastructural Study of Experimental Acrylamide Intoxication in the Cat, J. Neuropath. Exp. Neurol.28, 598 (1969).

    PubMed  Google Scholar 

  14. J.M. Schröder,Zur Pathogenese der Isoniazid-Neuropathie I. Eine feinstrukturelle Differenzierung gegenüber der Wallerschen Degeneration, Acta Neuropath.16, 301 (1970).

    PubMed  Google Scholar 

  15. M.I. Smith andR.D. Lillie,The Histopathology of Triorthocresyl Phosphate Poisoning, Arch. Neurol. Psychiat.26, 976 (1931).

    Google Scholar 

  16. P.S. Spencer andH.H. Schaumburg,Ultrastructural Studies of the Dying-Back Process IV. Differential Vulnerability of PNS and CNS Fibres in Experimental Central-Peripheral Distal Axonopathies, J. Neuropath. Exp. Neurol.36, 300 (1977).

    PubMed  Google Scholar 

  17. A.N. Worden,The Use of the Domestic Fowl in Neurotoxicity Studies, Thesis, 1972, pp. 1–169.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krinke, G., Ullmann, L., Sachsse, K. et al. Differential susceptibility of peripheral nerves of the hen to triorthocresyl phosphate and to trauma. Agents and Actions 9, 227–231 (1979). https://doi.org/10.1007/BF02024740

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02024740

Keywords

Navigation