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Isolation of maridomycins and structure of maridomycin II

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Zusammenfassung

Das ausStreptomyces hygroscopicus isolierte neue Makrolid Maridomycin II lässt sich mit Säure Mycarcose und Mycaminose spalten. Auf Grund der Oxidation ins Carbomycin sowie der spektroskopischen Daten wurde die Struktur als II erklärt.

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References

  1. MW, molecular weight; VPO, vapour pressure osmometry in ethyl acetate; MS, mass spectrum; MIC, minimum inhibitory concentration againstStaphylococcus aureus (mcg/ml); NMR, nuclear magnetic resonance spectrum in CDCl3 (δ (ppm)); IR, infrared spectrum (KBr, cm−1); UV, ultraviolet spectrum; TLC, thin layer chromatography (SiO2).

  2. s=singlet,d=doublet;dd=double doublet;t=triplet;q=quartet;oct=octet;m=multiplet; J=coupling constant.

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Authors and Affiliations

  1. Research and Development Division, Takeda Chemical Industries, Ltd., Osaka, (Japan)

    M. Muroi, M. Izawa, H. Ono, E. Higashide & T. Kishi

Authors
  1. M. Muroi
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  2. M. Izawa
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  3. H. Ono
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  4. E. Higashide
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  5. T. Kishi
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Additional information

The authors are greatly indebted to Dr.F. A. Hochstein of Chas Phizer & Co., Inc., for valuable gifts of carbomycin and carbomycin B.

Detailed microbiological and isolation studies will be published in J. Antibiotics (Tokyo).

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Muroi, M., Izawa, M., Ono, H. et al. Isolation of maridomycins and structure of maridomycin II. Experientia 28, 501–502 (1972). https://doi.org/10.1007/BF01931840

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  • DOI: https://doi.org/10.1007/BF01931840

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