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Interactions of a chemical carcinogen with neuro-endocrine factors in mouse breast cancer

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Zusammenfassung

Die Brustkrebsentwicklung bei intakten Mäusen des DBA8-Inzuchtstammes, welchen Hypophysen implantiert wurden, zeigt durch die perorale Verabreichung von 3-Methylcholanthren eine signifikante Beschleunigung. Entsprechend früheren Ergebnissen an einem anderen Krebsmodell5 hemmt auch in der Methylcholanthren-behandelten DBA-Maus der Zusatz von Hypothalamusgewebe die carcinogene Wirkung der implantierten Hypophyse.

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Authors and Affiliations

  1. Department of Pathology, University of Minnesota, Medical School, Minneapolis, Minnesota, U.S.A.

    E. Haus & F. Halberg

Authors
  1. E. Haus
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  2. F. Halberg
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Additional information

This investigation was aided by U.S.P.H.S. grants (C-5748, C-4359), the American Cancer Society (Minnesota Division and E-155), and Elsa U. Pardee Foundation.

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Haus, E., Halberg, F. Interactions of a chemical carcinogen with neuro-endocrine factors in mouse breast cancer. Experientia 18, 340–341 (1962). https://doi.org/10.1007/BF02151868

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