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A new inhibitor of decarboxylase of aromatic amino acids

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Zusammenfassung

N-(DL-Seryl)-N′-(2,3,4-trihydroxybenzyl)hydrazin (Ro 4-4602) bewriktin vitro starke Hemmung der Decarboxylase, die durch Pyridoxal-5′-phosphat nicht und durch Dialyse nur wenig vermindert werden kann. Nach i.p. Applikation der Substanz kommt es zu starker Verminderung der Decarboxylase-Aktivität und zu mässiger Herabsetzung von 5-Hydroxytryptamin und Noradrenalin in verschiedenen Organen. Monoaminoxydase des Gehirns wirdin vivo durch Ro 4-4602 nicht beeinflusst.

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Authors and Affiliations

  1. Medizinische Forschungsabteilung der F. Hoffmann-La Roche & Co. A.G., Basel, Switzerland

    W. P. Burkard, K. F. Gey & A. Pletscher

Authors
  1. W. P. Burkard
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  2. K. F. Gey
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  3. A. Pletscher
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Burkard, W.P., Gey, K.F. & Pletscher, A. A new inhibitor of decarboxylase of aromatic amino acids. Experientia 18, 411–412 (1962). https://doi.org/10.1007/BF02151490

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