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A study of the inhibition by cysteamine on the steroid 11β-hydroxylation

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  • Chimica, Biochimica
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Zusammenfassung

Cysteamine hemmt die Steroid 11 β-Hydroxylase schwächer als Metyrapon, jedoch stärker als Dithiole. Der Cysteamineffekt ist an die Konfiguration −SH−NH− gebunden, welche die Bildung gemischter Disulfide ermöglicht. Es werden Unterschiede im molekularen Mechanismus der Hemmwirkung zwischen den drei Stoffgruppen angenommen.

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Authors and Affiliations

  1. Abteilung Pharmakologie und Strahlenbiologie, Institut für Biophysik und Strahlenbiologie der Universität, Albertstrasse 23, D-7800, Freiburg, Federal Republic of Germany

    K. Flemming & Vera Seydewitz

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  1. K. Flemming
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  2. Vera Seydewitz
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Additional information

This work was supported by a grant (No. St. Sch. 257) of the Bundesminister für Forschung und Technologie, Bonn.

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Flemming, K., Seydewitz, V. A study of the inhibition by cysteamine on the steroid 11β-hydroxylation. Experientia 30, 989–991 (1974). https://doi.org/10.1007/BF01938963

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