Summary
The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evaluation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO holdtrans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydronaphthalene) incorporatestrans-transoid conformation and primarily acts on post-synaptic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.
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Dandiya, P.C., Sharma, H.L., Patni, S.K. et al. An evaluation of apomorphine action on dopaminergic receptors. Experientia 31, 1441–1443 (1975). https://doi.org/10.1007/BF01923234
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DOI: https://doi.org/10.1007/BF01923234