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Lipoperoxide formation in the retina in ocular siderosis

  • Pharmacologica
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Summary

Insertion of iron nail into the vitreous cavity provoked the formation of lipoperoxide in the retina. In accord with the increase in lipoperoxide in the retina, ERG began to decrease. In vitro experiment using isolated retina, lipoperoxide was found to be increased in the presence of ferric or ferrous ions, while it was inhibited by adding antioxidants or ethylenediamine tetraacetate. From these results, direct cause of retinal degeneration in siderosis could be ascribed to the formation of lipoperoxide by iron-ions liberated from the piece of iron, resulting into the degeneration of the visual cell layers of the retina.

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References

  1. T. Hiramitsu, Y. Hasegawa, K. Hirata, I. Nishigaki andK. Yagi, Experientia32, 622 (1976).

    Article  CAS  PubMed  Google Scholar 

  2. A. L. Tappel, Arch. Biochem. Biophys.44, 378 (1953).

    Article  CAS  PubMed  Google Scholar 

  3. A. L. Tappel, J. biol. Chem.217, 721 (1955).

    Article  CAS  PubMed  Google Scholar 

  4. A. Ottolengi, Arch. Biochem. Biophys.79, 355 (1959).

    Article  Google Scholar 

  5. E. D. Wills, Biochim. biophys. Acta84, 474 (1964).

    Google Scholar 

  6. E. D. Wills, Biochim. biophys. Acta98, 238 (1965).

    Article  CAS  PubMed  Google Scholar 

  7. E. D. Wills, Biochem. J.99, 667 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. F. Bernheim, M. L. C. Bernheim andK. M. Wilbur, J. biol. Chem.174, 257 (1948).

    Article  CAS  PubMed  Google Scholar 

  9. I. Nishigaki, T. Ozawa andK. Yagi, Vitamins38, 359 (1968).

    CAS  Google Scholar 

  10. H. Ōhama andK. Yagi, J. Vitamin.16, 297 (1970).

    Article  Google Scholar 

  11. H. Weiss andA. Graf, Albrecht v. Graefes Arch. klin. exp. Ophthal.197, 293 (1975).

    Article  CAS  Google Scholar 

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Hiramitsu, T., Majima, Y., Hasegawa, Y. et al. Lipoperoxide formation in the retina in ocular siderosis. Experientia 32, 1324–1325 (1976). https://doi.org/10.1007/BF01953119

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  • DOI: https://doi.org/10.1007/BF01953119

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