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Formation of lipoperoxide in isolated sciatic nerve by chinoform-ferric chelate

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  • Pharmacologica
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Summary

Effects of chinoform and chinoform-ferric chelate on formation of lipoperoxide in isolated sciatic nerve were investigated. Free chinoform did not increase the lipoperoxide level, while chinoform-ferric chelate significantly increased it. Assuming that the lipoperoxide formed denatures the associated protein in the nerve, the effect of chinoform-ferric chelate could explain, at least partly, the demyelination of nerve tissues caused by massive doses of chinoform.

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Author notes

  1. K. Yagi

    Present address: Institute of Biochemistry, Faculty of Medicine, University of Nagoya, 466, Nagoya, Japan

Authors and Affiliations

  1. Department of Biochemistry, Jikei University School of Medicine, 105, Tokyo, Japan

    Y. Yagi, M. Matsuda & K. Yagi

  2. Institute of Biochemistry, Faculty of Medicine, University of Nagoya, 466, Nagoya, Japan

    Y. Yagi & M. Matsuda

Authors
  1. Y. Yagi
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  2. M. Matsuda
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  3. K. Yagi
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Yagi, Y., Matsuda, M. & Yagi, K. Formation of lipoperoxide in isolated sciatic nerve by chinoform-ferric chelate. Experientia 32, 905–906 (1976). https://doi.org/10.1007/BF02003759

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  • DOI: https://doi.org/10.1007/BF02003759

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