Summary
An attempt was made to replicate the conflicting previous reports of hypo- and hyperthermic effects of intrahypothalamically administered carbachol. Despite using the same coordinates, injection parameters, and strain of rats reported by others, only hypothermia was conclusively demonstrated. It was concluded that the cholinergic system mediates heat loss mechanisms in rats.
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References
P. Lomax and D. J. Jenden, Int. J. Neuropharmac.5, 353 (1966).
P. Lomax, R. S. Foster and W. E. Kirkpatrick, Brain Res.15, 431 (1970).
W. E. Kirkpatrick and P. Lomax, Neuropharmacology9, 195 (1970).
P. Lomax, Int. Rev. Neurobiol.12, 1 (1970).
L. I. Crawshaw, J. Comp. Physiol. Psychol.83, 32 (1973).
M. L. Laudenslager and H. T. Carlisle, Pharmac. Biochem. Behav.4, 369 (1976).
D. D. Avery, Neuropharmacology10, 753 (1971).
D. D. Avery, J. Physiol. Lond.220, 257 (1972).
D. D. Avery and P. E. Penn, Pharmac. Biochem. Behav.1, 159 (1973).
D.DD. Avery and P. E. Penn, Neuropharmacology15, 433 (1976).
D. D. Avery, Neuropharmacology9, 175 (1970).
D.H. Overstreet, M. D. Kozar and G. S. Lynch, Neuropharmacology12, 1017 (1973).
W. E. Kirkpatrick, Life Sci.6, 2273 (1967).
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Netherton, R.A., Lee, P.S. & Overstreet, D.H. Are there 2 cholinergic thermoregulatory centres in rats?. Experientia 33, 1463–1464 (1977). https://doi.org/10.1007/BF01918809
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DOI: https://doi.org/10.1007/BF01918809