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Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats

  • Anotomica, Histologica, Embryologica, Carcinologica
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Summary

Treatment with propylthiouracil (PTU) resulted in a significant decrease in azoxymethane-induced intestinal tumors, total concentration of fecal bile acid as well as the fecal neutral steroids, cholesterol and coprostanol. Thus, a hypothyroid state induced by PTU treatment may affect intestinal carcinogenesis in this animal model by lowering the concentration of fecal bile acids and neutral steroids.

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Author notes

  1. D. V. Singh

    Present address: Division of Toxicology (HFF-152), Food and Drug Administration, 200 ‘C’ Street, S. W., 20204, Washington, D.C., USA

Authors and Affiliations

  1. Department of Surgery, Wayne State School of Medicine, 48201, Detroit, Michigan, USA

    D. V. Singh, R. L. Campbell, Y. N. Lin & N. D. Nigro

Authors
  1. D. V. Singh
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  2. R. L. Campbell
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  3. Y. N. Lin
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  4. N. D. Nigro
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Additional information

We would like to acknowledge the excellent technical assistance of Dale Miller, Kenneth Kohn, Mathew McGee and Michael McLaughlin. We also wish to thank Dr M. S. Pak for the histological work, and Ms Mary Acree and Ms Kathleen Smith for the excellent secretarial assistance. Supported by the Maltida R. Wilson Fund.

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Singh, D.V., Campbell, R.L., Lin, Y.N. et al. Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats. Experientia 33, 1516–1518 (1977). https://doi.org/10.1007/BF01918844

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  • DOI: https://doi.org/10.1007/BF01918844

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