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Hypertrophy of pulmonary arteries and arterioles with cor pulmonale in rats induced by seneciphylline, a pyrrolizidine alkaloid

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Summary

Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, induced, as do also monoclotaline, etc., a marked arterial and arteriolar hypertrophy of the lung of young Wistar rats a month after a single s. c. injection of 50–80 mg/kg. Cor pulmonale with leftward shift of the ventricular septum was also noted.

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Authors and Affiliations

  1. Department of Carcinogenesis and Cancer Susceptibility, Institute of Medical Science, University of Tokyo, Shirokanedai Minato-ku, 108, Tokyo, Japan

    K. Ohtsubo, Y. Ito, M. Saito, T. Furuya & M. Hikichi

  2. School of Pharmaceutical Science, Kitasato University, Shirokanedai Minato-ku, 108, Tokyo, Japan

    K. Ohtsubo, Y. Ito, M. Saito, T. Furuya & M. Hikichi

Authors
  1. K. Ohtsubo
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  2. Y. Ito
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  3. M. Saito
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  4. T. Furuya
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  5. M. Hikichi
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Ohtsubo, K., Ito, Y., Saito, M. et al. Hypertrophy of pulmonary arteries and arterioles with cor pulmonale in rats induced by seneciphylline, a pyrrolizidine alkaloid. Experientia 33, 498–499 (1977). https://doi.org/10.1007/BF01922233

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  • DOI: https://doi.org/10.1007/BF01922233

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