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A lack of correlation between rat kidney mitochondrial swelling and glutaminase activation in metabolic acidosis

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Summary

We found no overall correlation between mitochondrial swelling and PDG activity under many different conditions. We conclude that augmented PDG activity in acidosis is not related, at least to any great extent, to increased anion permeability produced by mitochondrial swelling.

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References

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Authors and Affiliations

  1. Nephrology Division, Department of Medicine, Georgetown University School of Medicine, 20007, Washington, D. C., USA

    T. A. Rakowski, L. L. Vertuno & H. G. Preuss

  2. Department of Pathology, Georgetown University School of Medicine, 20007, Washington, D. C., USA

    T. A. Rakowski, L. L. Vertuno & H. G. Preuss

Authors
  1. T. A. Rakowski
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  2. L. L. Vertuno
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  3. H. G. Preuss
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Additional information

Acknowledgments. Supported by NIH Grant AM 15458. The authors wish to express their appreciation to Betty Mendelson, Susan Dreux, and Patti Werr for secreterial assistance.

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Rakowski, T.A., Vertuno, L.L. & Preuss, H.G. A lack of correlation between rat kidney mitochondrial swelling and glutaminase activation in metabolic acidosis. Experientia 34, 359–360 (1978). https://doi.org/10.1007/BF01923034

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  • DOI: https://doi.org/10.1007/BF01923034

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