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Colony stimulating activity in acute and chronic endotoxinemia in man

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Summary

Blood granulocyte-macrophage colony stimulating activity (GM CSF) was measured in 6 normal individuals challenged with low-dose endotoxin and in 63 unselected patients with nonhaematological disorders. 5/63 patients were febrile and 5 other patients showed detectable endotoxin levels, as measured by the Limulus assay. CSA levels showed a rapid increase in normal individuals following endotoxin administration, but were in the normal range in patients with chronic endotoxinemia or in those with febrile disorders. Thus, unlike acute endotoxinemia, chronic endotoxinemia is not associated with elevated activity that promotes growth of myeloid commited stem cells. In addition, fever per se did not coincide with elevated blood CSA levels.

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Authors and Affiliations

  1. 1st Department of Medicine, Department of Gastroenterology and Hepatology, and Institute of Cancer Research, University of Vienna, Lazarettgasse 14, A-1090, Wien, Austria

    W. Hinterberger, L. Fridrich, P. Ferenci & W. Paukovits

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  1. W. Hinterberger
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  2. L. Fridrich
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  3. P. Ferenci
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  4. W. Paukovits
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Hinterberger, W., Fridrich, L., Ferenci, P. et al. Colony stimulating activity in acute and chronic endotoxinemia in man. Experientia 35, 1398–1400 (1979). https://doi.org/10.1007/BF01964032

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