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Acid excretion in young and adult Wistar Kyoto and spontaneously hypertensive rats

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Summary

Wistar Kyoto rats (WKy), the most widely accepted control for SH rats, show an inability to excrete acid appropriately when compared to another normotensive strain, SD. Coupled with the fact that KWy also develops ‘sodium-sensitive’ hypertension, this makes them a more complex control than realized. At very young ages (<10-week-old), neither SH nor WKy show any deficiency in acid excretion.

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Authors and Affiliations

  1. Department of Medicine and Pathology, Georgetown University School of Medicine, 20007, Washington, DC, USA

    M. Belledonne, J. M. Preuss & H. G. Preuss

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  1. M. Belledonne
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  2. J. M. Preuss
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  3. H. G. Preuss
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Additional information

Acknowledgments. Supported by AHA grant 76 1019 and NIH grant AM 15458. The excellent secretarial help of Susan Dreux and Betty Mendelson is acknowledged.

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Belledonne, M., Preuss, J.M. & Preuss, H.G. Acid excretion in young and adult Wistar Kyoto and spontaneously hypertensive rats. Experientia 35, 1594–1595 (1979). https://doi.org/10.1007/BF01953213

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  • DOI: https://doi.org/10.1007/BF01953213

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