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A selective concentration-dependent dysrhythmogenic and antidysrhythmic action of prostaglandins E2, F2α and I2 (prostacyclin) on isolated rat hearts

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Summary

Prostaglandins (PGs) E2, F2α, and I2 were examined for their effects on the electrical and mechanical activities of isolated rat, rabbit and guinea-pig hearts. All PGs produced dysrhythmias in rat hearts at low concentrations only, while higher concentrations were antiarrhythmic. Guinea-pig hearts were less responsive while rabbit hearts were completely resistant.

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Authors and Affiliations

  1. Division of Experimental Cardiology, Department of Physiology, Faculty of Medicine, University of Manitoba, 770 Bannatyne Avenue, R3E OW3, Winnipeg, Manitoba, Canada

    M. Karmazyn & N. S. Dhalla

Authors
  1. M. Karmazyn
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  2. N. S. Dhalla
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Additional information

We thank the Manitoba Heart Foundation for financial support and Dr J. Pike (Upjohn, Kalamazoo, MI, USA) for gifts of prostaglandins. Dr M. Karmazyn is a Fellow of the Canadian Heart Foundation.

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Karmazyn, M., Dhalla, N.S. A selective concentration-dependent dysrhythmogenic and antidysrhythmic action of prostaglandins E2, F2α and I2 (prostacyclin) on isolated rat hearts. Experientia 36, 996–998 (1980). https://doi.org/10.1007/BF01953843

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