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Mast cell stabilizing compound FPL 55618 reduces right ventricular hypertrophy and lung mast cell hyperplasia in chronically hypoxic rats

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Summary

Rats treated with chronic hypobaric hypoxia (21 days, 380 Torr) and mast cell stabilizing compund FPL 55618 had significantly less right ventricular hypertrophy and lung mast cell hyperplasia than rats subjected to chronic hypoxia alone. Right ventricular blood pressure was not reduced.

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Authors and Affiliations

  1. Department of Pathology, McMaster University, L8N 3Z5, Hamilton, Ontario, Canada

    J. M. Kay, K. L. Suyama & P. M. Keane

Authors
  1. J. M. Kay
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  2. K. L. Suyama
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  3. P. M. Keane
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Additional information

Compound FPL 55618 was kindly donated by Mr P. Sheard of Fisons Ltd Pharmaceutical Division, Loughborough, Leicestershire, LE11 OQY England.

This study was supported by grants from the Medical Research Council of Canada and St. Joseph's Hospital Foundation.

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Kay, J.M., Suyama, K.L. & Keane, P.M. Mast cell stabilizing compound FPL 55618 reduces right ventricular hypertrophy and lung mast cell hyperplasia in chronically hypoxic rats. Experientia 37, 75–76 (1981). https://doi.org/10.1007/BF01965579

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