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6-Geranyloxy-3-methyl-1,8-dihydroxyanthrone, a novel antileukemic agent fromPsorospermum febrifugum Sprach var.ferrugineum (Hook. fil)

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Summary

A systematic fractionation of the root extract ofPsorospermum febrifugum was carried out in an attempt to reisolate the antitumor xanthone psorospermin and related compounds for further structural work and testing. This activitydirected fractionation led to the isolation of 6-geranyloxy-3-methyl-1,8-dihydroxyanthrone (1). Compound (1) was characterized based on spectroscopic and chemical evidence and showed borderline but reproducible activity in the P-388 mouse leukemia system.

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Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    A. Amonkar, C. -j. Chang & J. M. Cassady

Authors
  1. A. Amonkar
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  2. C. -j. Chang
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  3. J. M. Cassady
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Additional information

The authors acknowledge the support from USDA for collection of the plant material and the National Cancer Institute for support of this work under contract No. NO1-CM-97296. This is paper 15 in the series ‘Potential Antitumor Agents’.

Cytotoxicity was assayed under the auspices of contract No. NO1-CM-97296. The Division of Cancer Treatment, National Cancer Institute, National Institute of Health, Bethesda, Maryland awarded support for this work.

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Amonkar, A., Chang, C.j. & Cassady, J.M. 6-Geranyloxy-3-methyl-1,8-dihydroxyanthrone, a novel antileukemic agent fromPsorospermum febrifugum Sprach var.ferrugineum (Hook. fil). Experientia 37, 1138–1139 (1981). https://doi.org/10.1007/BF01989881

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  • DOI: https://doi.org/10.1007/BF01989881

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