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Steroid-induced concentric membrane whorls in dog liver

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Summary

When daily doses of 10 mg/kg of the androgenic steroids fluoxymesterone, methyltestosterone, testosterone propionate, oxymetholone and mepitiostane were administered to adult male and female beagle dogs for 6 months, concentric membrane whorls were produced in the hepatocytes of all groups. The whorls frequently had a central core mainly composed of lipids or mitochondria and the membranes of the whorls, consisting of paired membranes, continued to the smooth or granular endoplasmic reticulum at the periphery of the structures.

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Authors and Affiliations

  1. Shionogi Research Laboratory at Aburahi, Koga-cho, Koga-gun, Shiga-ken, Japan

    Y. Muraoka, I. Yahara, H. Nara & H. Watanabe

Authors
  1. Y. Muraoka
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  2. I. Yahara
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  3. H. Nara
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  4. H. Watanabe
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Muraoka, Y., Yahara, I., Nara, H. et al. Steroid-induced concentric membrane whorls in dog liver. Experientia 37, 389–390 (1981). https://doi.org/10.1007/BF01959879

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  • DOI: https://doi.org/10.1007/BF01959879

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