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Blockade of nicotinic receptors in brain with d-tubocurarine induces decreased metabolism, cutaneous vasodilation and hypothermia in rats

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Summary

Direct administration of d-tubocurarine into the lateral cerebral ventricle of conscious rats produced decreased metabolism, cutaneous vasodilatation and hypothermia at ambient temperatures of 8–22°C. Also, pretreatment with d-tubocurarine antagonized the arecoline-induced hypothermia.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan

    M. T. Lin & A. Chandra

Authors
  1. M. T. Lin
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  2. A. Chandra
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Additional information

This work was supported by grants from the National Science Council of Republic of China and the Pjing-Ling Neurological Foundation (Veterans General Hospital, Taipei, Taiwan).

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Lin, M.T., Chandra, A. Blockade of nicotinic receptors in brain with d-tubocurarine induces decreased metabolism, cutaneous vasodilation and hypothermia in rats. Experientia 37, 986–988 (1981). https://doi.org/10.1007/BF01971795

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  • DOI: https://doi.org/10.1007/BF01971795

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