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Effect of free fatty acids and cholesterol in vitro on liver plasma membrane-bound enzymes

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Summary

The effect of cholesterol and fatty acid treatment in vitro was tested on rat liver plasma membrane-bound enzymes and lipid fluidity. The observed alterations of membrane fluidity affect both (Na+−K+)-ATPase and Mg2+-ATPase activities but not 5′-nucleotidase; basal adenylate cyclase as well as its hormonal sensitivity were differentially affected by changes of membrane microenvironment.

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Authors and Affiliations

  1. Institute of General Physiology, University of Rome, I-00185, Rome, Italy

    S. Leoni, P. Luly, M. T. Mangiantini & S. Spagnuolo

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  1. S. Leoni
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  2. P. Luly
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  3. M. T. Mangiantini
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  4. S. Spagnuolo
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Additional information

This investigation was partially supported by the Italian National Research Council.

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Leoni, S., Luly, P., Mangiantini, M.T. et al. Effect of free fatty acids and cholesterol in vitro on liver plasma membrane-bound enzymes. Experientia 38, 102–104 (1982). https://doi.org/10.1007/BF01944552

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