Skip to main content
SpringerLink
Log in

Degeneration of retinal neuroblasts by chinoform-ferric chelate

  • Published:
Experientia Aims and scope Submit manuscript

Summary

The possible mechanism of neuropathic effect of chinoform was investigated using cultured retinal neuroblasts from chick embryos. Retinal neuroblasts completely degenerated by chinoform-ferric chelate within a day. This change, however, was not observed with free chinoform or ferric ion.a-Tocopherol had a potent protective effect on the toxicity of the chelate. From these results, it was concluded that the lipid peroxidation due to ferric ion chelated with chinoform incorporated into the membrane of nerve tissues is the most important step in induction of the neuropathy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T. Tsubaki, Y. Honma and M. Hoshi, Lancet1, 696 (1971).

    Article  CAS  PubMed  Google Scholar 

  2. K. Nakae, S. Yamamoto, I. Shigematsu and R. Kono, Lancet1, 171 (1973).

    Article  CAS  PubMed  Google Scholar 

  3. M. Ogata, S. Watanabe, J. Tateishi, S. Kuroda and S. Otsuki, Lancet1, 1248 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. M. Ogata, S. Watanabe, J. Tateishi, S. Kuroda and S. Otsuki, Lancet1, 1325 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. Z. Tamura, M. Yoshioka, T. Imanari, J. Fukaya, J. Kusaka and K. Samejima, Clin. chim. Acta47, 13 (1973).

    Article  CAS  PubMed  Google Scholar 

  6. Y. Yagi, M. Matsuda and K. Yagi, Experientia32, 905 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. T.S. Okada, Y. Itoh, K. Watanabe and G. Eguchi, Devl Biol.45, 318 (1975).

    Article  CAS  Google Scholar 

  8. A.L. Tappel, Fedn Proc.32, 1870 (1973).

    CAS  Google Scholar 

  9. T. Hiramitsu, Y. Hasegawa, K. Hirata, I. Nishigaki and K. Yagi, Experientia32, 622 (1976).

    Article  CAS  PubMed  Google Scholar 

  10. K. Yagi, S. Matsuoka, H. Ohkawa, N. Ohishi, Y.K. Takeuchi and H. Sakai, Clin. chim. Acta80, 355 (1977).

    Article  CAS  PubMed  Google Scholar 

  11. K.N. Prasad, P.K. Sinha, M. Ramanujam and A. Sakamoto, Proc. natl Acad. Sci. USA76, 829 (1979).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biochemistry, Faculty of Medicine, University of Nagoya, 466, Nagoya

    K. Ohtsuka, N. Ohishi, G. Eguchi & K. Yagi

  2. Institute of Molecular Biology, Faculty of Science, Nagoya University, 464, Nagoya, Japan

    K. Ohtsuka, N. Ohishi, G. Eguchi & K. Yagi

Authors
  1. K. Ohtsuka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Ohishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Eguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Yagi
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported in part by a grant from the Ministry of Health and Welfare of Japan.

Correspondence should be addressed to K. Yagi, Institute of Biochemistry, Faculty of Medicine, University of Nagoya, Nagoya 466, Japan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ohtsuka, K., Ohishi, N., Eguchi, G. et al. Degeneration of retinal neuroblasts by chinoform-ferric chelate. Experientia 38, 120–122 (1982). https://doi.org/10.1007/BF01944564

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01944564

Keywords

Search

Navigation