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Difference in proliferation-kinetics between tumor cells arrested in the brain and liver

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Summary

To elucidate the mechanisms of organ specificity of cancer metastasis, rat ascites hepatoma AH7974F cells were injected into rat carotid artery. Tumors were found in the liver, but rarely in the brain. Analysis of proliferation-kinetics of tritiated thymidine-labeled tumor cells arrested in the brain and liver made it clear that tumor cells arrested in the brain remained viable, but ceased dividing, while almost all of the tumor cells arrested in the liver divided.

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Authors and Affiliations

  1. 2nd Department of Pathology, Central Laboratory, Division of Cell Science, Fukushima Medical College, 960, Fukushima, Japan

    T. Kawaguchi, M. Endo, S. Yokoya & K. Nakamura

Authors
  1. T. Kawaguchi
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  2. M. Endo
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  3. S. Yokoya
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  4. K. Nakamura
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Additional information

We thank Professor Garth L. Nicolson of The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, for revision of this manuscript. This work was supported by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan.

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Kawaguchi, T., Endo, M., Yokoya, S. et al. Difference in proliferation-kinetics between tumor cells arrested in the brain and liver. Experientia 38, 1236–1237 (1982). https://doi.org/10.1007/BF01959761

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  • DOI: https://doi.org/10.1007/BF01959761

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