Summary
Sodium diethyldithiocarbamate, 2,6-di-tert-butylphenol and N,N′-diphenyl-p-phenylenediamine inhibited the generation of medullary prostaglandin E, but 1,2-dimethoxyethane (OH scavenger) and 2,5-dimethylfuran (1O2 scavenger) stimulated basal prostaglandin E production 1.2–1.3-fold. These results suggest that the balance between formation and removal of cellular lipid peroxides sets a peroxide level that can regulate the rate of prostaglandin formation in cells.
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Fujita, T., Fujimoto, Y. & Tanioka, H. Antioxidant effects on prostaglandin synthesis in rabbit kidney medulla slices. Experientia 38, 1472 (1982). https://doi.org/10.1007/BF01955777
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DOI: https://doi.org/10.1007/BF01955777