Caclium causes the biphasic dose-response curve for pancreatic amylase secretion

Summary

High concentrations of bethanechol (10⁻⁴ to 10⁻³ M) were effective stimulants of amylase secretion from the mouse pancreas if incubations are performed in low [ca²⁺] (0.1 mM) solutions but not if normal Krebs solution (2.56 mM Ca²⁺) was used. This inhibitory effect of Ca²⁺ at high secretagogue concentrations did not appear to be mediated through the microtubules or microfilaments.