Skip to main content
SpringerLink
Log in

Urinary acidic glycosaminoglycans in Werner's syndrome

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The composition of urinary acidic glycosaminoglycans (AGAG) in 4 patients with Werner's syndrome was determined by an enzymatic assay system using chondroitinases and hyaluronidase. In Werner's syndrome, the amount of hyaluronic acid and heparan sulfates in the total AGAG increases. A compositional change in the chondroitin sulfate isomers occurs. The change of urinary AGAG in Werner's syndrome appears to reflect age-related changes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C.W.O. Werner, Doctoral dissertation, Schmidt and Klauning, Kiel 1904.

    Google Scholar 

  2. W. Reichel, R. Garcia-Bunuel and J. Dilallo, J. Am. Geriat. Soc.19, 369 (1971).

    Article  CAS  PubMed  Google Scholar 

  3. C.J. Epstein, G.M. Martin, A.L. Schultz and A.G. Motulsky, Medicine45, 177 (1966).

    Article  CAS  PubMed  Google Scholar 

  4. R. Fleischmajer and A. Nedwich, Am. J. Med.54, 111 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. D.P. Varadi, J.A. Cifonelli and A. Dorfman, Biochim. biophys. Acta141, 103 (1967).

    Article  CAS  PubMed  Google Scholar 

  6. K. Murata, T. Harada, T. Fujiwara and T. Furuhashi, Biochim. biophys. Acta230, 583 (1971).

    Article  CAS  PubMed  Google Scholar 

  7. N. Taniguchi, Clinica chim. Acta37, 225 (1972).

    Article  CAS  Google Scholar 

  8. E. Wessler, Biochem. J.122, 373 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. H. Saito, T. Yamagata and S. Suzuki, J. biol. Chem.243, 1536 (1968).

    Article  CAS  PubMed  Google Scholar 

  10. K. Murata, in: Methods in Carbohydrate Chemistry, vol. 8, p. 79. Eds R.L. Whistler and J.N. BeMiller. Academic Press, New York 1980.

    Google Scholar 

  11. T. Bitter and H.M. Muir, Analyt. Biochem.4, 330 (1962).

    Article  CAS  PubMed  Google Scholar 

  12. K. Murata, T. Ishikawa and H. Ninomiya, Biochem. Med.8, 472 (1973).

    Article  CAS  Google Scholar 

  13. K. Murata and M. Takeda, Clinica chim. Acta108, 49 (1980).

    Article  CAS  Google Scholar 

  14. M. Tokunaga, E. Wakamatsu and Z. Yoshizawa, Clinica chim. Acta62, 89 (1975).

    Article  CAS  Google Scholar 

  15. M. Goto and K. Murata, Clinica chim. Acta85, 101 (1978).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine and Physical Therapy, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    K. Murata

Authors
  1. K. Murata
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The study was supported, in part, by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, the Life Science of the Institute of Physical and Chemical Research and the Adult Disease Clinic Memorial Foundation, Tokyo. Thanks are due to Dr Y. Yamada and Dr R. Abe for collecting specimens, and Miss R. Abe and Miss R. Yamaguchi for technical assistance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Murata, K. Urinary acidic glycosaminoglycans in Werner's syndrome. Experientia 38, 313–314 (1982). https://doi.org/10.1007/BF01949362

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01949362

Keywords

Search

Navigation