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Studies on the in vitro binding of D-penicillamine to cholestyramine

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Summary

Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4–8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/1) inhibited this small adsorption by 87%.

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Authors and Affiliations

  1. Department of Internal Medicine II, Klinikum Grosshadern, University of Munich, Marchioninistr. 15, D-8000, München 70, Federal Republic of Germany

    H. Allgayer, W. Kruis & G. Paumgartner

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  1. H. Allgayer
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  2. W. Kruis
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  3. G. Paumgartner
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Allgayer, H., Kruis, W. & Paumgartner, G. Studies on the in vitro binding of D-penicillamine to cholestyramine. Experientia 38, 482–484 (1982). https://doi.org/10.1007/BF01952651

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  • DOI: https://doi.org/10.1007/BF01952651

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