Summary
When cells were irradiated with variable doses of gamma rays, 0.33% showed the appearance of single decondensed chromosomes (SDC) at the moment at which all the other chromosomes of the complement exhibited the normal condensed state corresponding to metaphase stages. Several hypotheses are discussed to explain the origin of SDC. It appears that the most reasonable mechanism to explain our observations is to assume that the process of chromosome condensation is independently controlled in each individual chromosome by a gene/s located in each one of the chromosomes of the complement. A radiation-induced deficiency in one of these genes may produce an impairement in the normal process of condensation of the carrier chromosome which would give rise to SDC.
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References
F.H.C. Crick, Nature234, 25 (1971).
J.H. Frenster, in: The chromosome. Structural and functional aspects, p. 78. Ed. G. Yerganian. Tissue Culture, 1965.
J.H. Hozier, in: Molecular genetics, part 3. p. 35. Ed. J.H. Taylor. Academic Press, New York 1979.
D. Mazia, J. Cell comp. Physiol.62, suppl 1, 123 (1963).
E.T. Johnson, P.N. Rao and S.D. Hughes, J. Cell Physiol.76, 151 (1970).
R.T. Johnson and P.N. Rao, Nature236, 175 (1970).
S.L. Schor, R.T. Johnson and C.A. Waldren, J. Cell Sci.15, 539 (1975).
E. Heitz, Ber. dt. bot. Ges.47, 275 (1929).
C.D. Darlington, Ann. Bot.5, 203 (1941).
A.M. Mullinger and R.T. Johnson, J. Cell Sci.46, 61 (1980).
J.R. Paulson and U.K. Laemmli, Cell12, 817 (1977).
A. Cole, R.E. Meyn, R. Chen, P.M. Corry and W. Hittelman, in: Radiation biology in cancer research, p. 33. Eds. R.E. Meyn and H. Rodney-Withers. Raven Press, New York 1980.
United Nations Scientific Committee on the Effects of Atomic Radiation, Ionizing Radiation: Levels and Effects, vol.2. Effects A/8725: General Assembly Official Records 27th Session, suppl. No. 25 (United Nations).
C. Redi, E. Capanna and N. O. Bianchi, in preparation.
S. Abrahmson, M.A. Bender, A.D. Conger and S. Wolff, Nature245, 460 (1973).
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This work was supported by grants from CIC and CONICET.
Acknowledgments. I wish to thank Dr J.M. Andrieu who kindly performed the irradiation of the specimens.
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Bianchi, N.O. Gene controlled condensation in individual chromosomes. Experientia 38, 792–794 (1982). https://doi.org/10.1007/BF01972274
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DOI: https://doi.org/10.1007/BF01972274