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Monoamine oxidase inhibition by d-amphetamine in ganglia and nerve endings

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Summary

The inhibition of monoamine oxidase (MAO) activity by d-amphetamine was measured in homogenates of cat superior cervical ganglion and nictitating membrane, using tyramine (TM) and noradrenaline (NA) as substrates. In both tissues, d-amphetamine was shown to be a competitive inhibitor of the oxidation of TM. The Ki for d-amphetamine, as a MAO inhibitor, was lower in the ganglia than in the peripheral nerve endings.

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Authors and Affiliations

  1. Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Junín 956, 1113, Buenos Aires, Argentina

    E. J. Filinger & F. J. E. Stefano

Authors
  1. E. J. Filinger
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  2. F. J. E. Stefano
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Additional information

Supported by a Contract from the National Research Council of Argentina (CONICET) (Res. 67/79).

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Filinger, E.J., Stefano, F.J.E. Monoamine oxidase inhibition by d-amphetamine in ganglia and nerve endings. Experientia 38, 844–845 (1982). https://doi.org/10.1007/BF01972307

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  • DOI: https://doi.org/10.1007/BF01972307

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